The Mid-Ohio Valley Regional Airport (MOVRA) is located less than seven miles from Marietta in nearby Wood County, West Virginia, and offers flights to Cleveland, Pittsburgh, and Charlotte, NC with access to national and international destinations. Washington County through a unique arrangement with Wood County (WV) participates in the governance of the airport.

Yeager Airport in Charleston, West Virginia, is located 92 miles away via I-77. Yeager Airport offers non-stop flights via five airlines to 11 airports in the eastern United States.

Akron-Canton airport is located 114 miles from Marietta on interstate 77.

Port Columbus International Airport is located 125 miles from downtown Marietta via I-77 and I-70 in Columbus, Ohio. Port Columbus is served by 11 airlines, offers non-stop flights to 35 airports, and had over 2.3 million passengers in 2013.

Pittsburgh International Airport is located 137 miles from Marietta and can be easily reached by Interstate highways I-77 and I-70.